'Chemotherapy can cause damage to healthy cells, which triggers them to secrete a protein that sustains tumor growth and makes cancer more resistance to any further treatment. We are beginning to see clinical evidence across the board show that what happens to healthy cells during cancer treatment determines much if not the entire outcome of treatment.
“Cancer cells inside the body live in a very complex environment or neighborhood. Where the tumor cell resides and who its neighbors are influence its response and resistance to therapy,” said senior author Dr. Peter S. Nelson, a member of the Hutchinson Cancer Center’s Human Biology Division. “Our findings indicate that the tumor microenvironment also can influence the success or failure of these more precise therapies.” In other words, the same cancer cell, when exposed to different “neighborhoods,” may have very different responses to treatment.'
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